COVID-19 highlights the critical connection between the health of nature and human health. This connection must be better reflected in our priorities, policies and actions. The root causes of this pandemic are common to many root causes of the climate change and biodiversity crises. Confronting these intertwined crises requires an integrated approach and unprecedented cooperation to achieve an equitable carbon-neutral, nature-positive economic recovery and a sustainable future. Our organizations’ recommendations to policymakers for meeting this challenge are offered below.